Basic Information
VIS ID
TVIS10010478
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
8390785/8390552 (Hg38)
End
8390785/8390552 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3691/Upstream/2221117; hsa-mir-10398/Downstream/2049165;
Nearest TSS
ENST00000381078/Upstream/47531; ENST00000645232/Downstream/44931;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/287853, chr6-CpG: 68/Downstream/44529
Nearby gene
EEF1E1-BLOC1S5(-287957) ; SLC35B3(+22516) ;
Upstream sequence
CAGcagagtagaattttattacctttgaccaaaatcattctaaggacacttaatacagcaaaggacaggtacatgtaatctttaaaataacttacaaaga
Downstream sequence
tcctcctgcctcagcctcccaaatagctgggattacaggtgtgcaccaccatgcccaggtaattttttttttttttttgacttttagtggagatggggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate