Basic Information
VIS ID
TVIS10010480
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1639
Orient
-
Integrated sequence
ACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATA| |TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG
Host Sequence
Chromosome
chr7
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
35742815/35703205 (Hg38)
End
35742815/35703205 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7C
Nearest miRNA
hsa-mir-1183/Upstream/762371; hsa-mir-10399/Downstream/1216152;
Nearest TSS
ENST00000635602/Upstream/7634; ENST00000430518/Downstream/11829;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/7836, chr7-CpG: 117/Downstream/97317
Nearby gene
HERPUD2(-8043) ; SEPTIN7(+97781) ;
Upstream sequence
GTTAATTACACTTGGTAAAATCTTTGATCAAAGCTTAATTTTGTggctgggcgcagtggctcatgcctgtaatcccagcactttgggaggctgaggcggg
Downstream sequence
cccaaagtgctgggattacaggcataagccactgcgcccagcctataagtgataattctttatacttaaccttccatgttcaaaatgtggtgtggtttct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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