Basic Information
VIS ID
TVIS10010482
Fusion event
HBV-LOC107986806 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1639
Orient
-
Integrated sequence
ACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATA| |TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
63378784/63918406 (Hg38)
End
63378784/63918406 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
LOC107986806
Nearest miRNA
hsa-mir-1183/Upstream/297237; hsa-mir-10399/Downstream/760658;
Nearest TSS
ENST00000635602/Upstream/17583; ENST00000330020/Downstream/80468;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/17291, chr7-CpG: 23/Downstream/7824
Nearby gene
MIR4283-1(-297237) ; LINC01005(+106012) ;
Upstream sequence
ggaagggagggCGGAGGGAAGGAAGAATTAGAGgaaagaaagaaagaaggaaagaaggaaagaaggagaaaaaaagaaagaaaagaaagaaaggaaaaga
Downstream sequence
cccaaagtgctgggatcacaggcatgaggcaccgcacccggcTGCTTCTTGCAAGTTTTTGAACGTGTCAGTGAAGAAGCAGTTGTGTCATTTTGTGAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate