Basic Information
VIS ID
TVIS10010483
Fusion event
HBV-GTF2IP23 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
66338486/66873499 (Hg38)
End
66338486/66873499 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
GTF2IP23
Nearest miRNA
hsa-mir-1183/Upstream/2194323; hsa-mir-10399/Downstream/240823;
Nearest TSS
ENST00000635602/Upstream/76127; ENST00000610177/Downstream/29358;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/28446, chr7-CpG: 21/Downstream/28480
Nearby gene
GTF2IRD1P1(-28673) ; TMEM248(+47717) ;
Upstream sequence
ggaaagaaggagaaaaaaagaaagaaaagaaagaaaggaaaagaaaaaagaaaagaaaaggaagatgaaaagaagaaaggaaggaagaaggcaagggaag
Downstream sequence
aaaaaGTGCTGGGATTACAGGCGTGAGCCAACATGTTTGCATTTATCTAGTTGAAGCTACGAGGAGGTAGGAGGGCCTAGTTGTCCTTGGTGTTTTGACG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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