Basic Information
VIS ID
TVIS10010487
Fusion event
HBV-CASTOR3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99848755/100251132 (Hg38)
End
99848755/100251132 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
CASTOR3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6749-3p ; hsa-mir-3182 ; hsa-mir-2116-3p ; hsa-mir-6729-3p ; hsa-mir-4286
Nearest miRNA
hsa-mir-10525/Upstream/94463; hsa-mir-10399/Downstream/105519;
Nearest TSS
ENST00000635602/Upstream/4584; ENST00000380765/Downstream/21055;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/73172, chr7-CpG: 114/Downstream/20248
Upstream sequence
AGAAGTACAGAATGCTAAATGGTATGAGGTGTTATCTCTACTGAACTGAACTCCTAGTCTCCCTGCCCCCTGACATTTCTAATCAGGAAGCTGGCCCACT
Downstream sequence
gcttgagcccaggaggtccaggctgcagtgagctataactgcactactgcactccagcctgggcaaagcaagaccctgtctcaattaaaaaaaaaaaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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