Basic Information
VIS ID
TVIS10010501
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chrX
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
101351750/102096778 (Hg38)
End
101351750/102096778 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/7033552; hsa-mir-105-1/Downstream/4543036;
Nearest TSS
ENST00000429181/Upstream/164747; ENST00000476749/Downstream/28910;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/164493, chrX-CpG: 27/Downstream/28911
Nearby gene
ZMAT1(-164711) ; TCEAL2(+28910) ;
Upstream sequence
gccgaggcaggcggatcactggaggtcaggagttcgagaccagtctggccaacatggcaaaaccccatctcgactaaaaatacaaaaattagccaggctt
Downstream sequence
aagtgctgggattacaggcgtgagccaccgtgccccgccaaaacttttttgtaaaaaactaagacaggaggcggggccaagatggccgactagaaacagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate