Basic Information
VIS ID
TVIS10010506
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
226
Orient
+
Integrated sequence
TTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAA| |GAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAAC
Host Sequence
Chromosome
chrY
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
13453683/11298007 (Hg38)
End
13453683/11298007 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-2/Upstream/6691779; hsa-mir-12120/Downstream/2181170;
Nearest TSS
ENST00000430575/Upstream/1387209; ENST00000417071/Downstream/1364327;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/82965, chrY-CpG: 92/Downstream/8908
Nearby gene
GYG2P1(+1064232) ;
Upstream sequence
ccaacttcatttcattgtgttccattccattccattccactccattccattccattctttctttcgagagtatctcactctgttaccaagcctagagcac
Downstream sequence
attccattccattccattccattcctttccactctggtttattcaattccattctatgaaattccattccattccattccattatattccatttccttcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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