Basic Information
VIS ID
TVIS10010514
Fusion event
HBV-C1orf167 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1769
Orient
-
Integrated sequence
GGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCT| |TTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAA
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
11822785/11762728 (Hg38)
End
11822785/11762728 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
C1orf167
Nearest miRNA
hsa-mir-12136/Upstream/1795270; hsa-mir-101-1/Downstream/266430;
Nearest TSS
ENST00000473358/Upstream/941; ENST00000484153/Downstream/4014;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/422, chr1-CpG: 92/Downstream/42677
Nearby gene
AGTRAP(-11957) ; MTHFR(+23002) ;
Upstream sequence
agctcctgtcctcatttctaaaacagggaacctaagtcccagggctgcagtgcagattaaatggcaggacgcctgctgaaggctgcaaggtgcctagcac
Downstream sequence
ggttgtcatttattcaatgtgcatttacaagcccctgctgggggtcaggcattgttctatgggctgcaaatccagcagggaaacaaacaaacaaaaaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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