Basic Information
VIS ID
TVIS10010515
Fusion event
HBV-C1orf167 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1842
Orient
+
Integrated sequence
TGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATC| |ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
11822868/11762811 (Hg38)
End
11822868/11762811 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
C1orf167
Nearest miRNA
hsa-mir-12136/Upstream/1795353; hsa-mir-101-1/Downstream/266347;
Nearest TSS
ENST00000473358/Upstream/1024; ENST00000484153/Downstream/3931;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/505, chr1-CpG: 92/Downstream/42594
Nearby gene
AGTRAP(-12040) ; MTHFR(+22919) ;
Upstream sequence
tgcaaggtgcctagcacggttgtcatttattcaatgtgcatttacaagcccctgctgggggtcaggcattgttctatgggctgcaaatccagcagggaaa
Downstream sequence
caaacaaacaaaaaaaaccagcctgccctcgtgtggctcctaggccactggagggagaaatacactaatttcttcactatgttaggtggccgcaagtgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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