VISDB Viral Integration Site DataBase

VIS ID

TVIS10010520

Fusion event

HBV-SETDB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1774

Orient

-

Integrated sequence

CTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTA| |CTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTC

Chromosome

chr1

Cytoband

q21.3

Reference genome

Start

End

150924716/150952240 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-296-3p ; hsa-mir-324-3p ; hsa-mir-152-3p ; hsa-mir-92a-3p ; hsa-mir-1260b ; hsa-mir-29a-3p ; hsa-let-7c-5p ; hsa-mir-1296-5p ; hsa-mir-2909 ; hsa-mir-3689d ; hsa-mir-4286 ; hsa-mir-4434 ; hsa-mir-4443 ; hsa-mir-4512 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-6134 ; hsa-mir-6515-5p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6895-5p ; hsa-mir-7160-3p

Nearest miRNA

hsa-mir-101-1/Upstream/400226; hsa-mir-1182/Downstream/593556;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/25877, chr1-CpG: 136/Downstream/21780

Nearest cancer related gene

SETDB1(OG, No orient, 0)

Upstream sequence

tctgccttaaaaaaaaaaaaagaaaagttagaatcaaattcatggtgctcttacaggattttaagctgccaagtgatgtgacctgcctttttcagattac

Downstream sequence

tctggcttctttgtagatcataggtcttaggatggcaaaagtagattttggaagaccaattaggagatcgttataggagtacagcagagagagacattgt