Basic Information
VIS ID
TVIS10010522
Fusion event
HBV-LINC01699 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
268
Orient
+
Integrated sequence
ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT| |CTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGG
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
181204676/181235540 (Hg38)
End
181204676/181235540 (Hg38)
Orient
+
Location type
upstream
Target gene
LINC01699
Nearest miRNA
hsa-mir-101-1/Upstream/797150; hsa-mir-1182/Downstream/11480788;
Nearest TSS
ENST00000473358/Upstream/44391; ENST00000319701/Downstream/848;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/129674, chr1-CpG: 52/Downstream/82624
Upstream sequence
cactggaacccaggaggtcaaggctgcagtgtgctatgatcatgtctatgaatagccactgcacgccaacctgggcagcatagtgagaccccatctcaaa
Downstream sequence
taataaaaaaaGGTCTTCAGGAGATTTTGATATATAACTAGCTATGGAACTCATTGTAGTGCTGATTTGCCTTTTCTGCCTGTTTTATTTTGTTTTAGTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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