Basic Information
VIS ID
TVIS10010524
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1832
Orient
+
Integrated sequence
TGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT| |CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
185674893/185705761 (Hg38)
End
185674893/185705761 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/5267371; hsa-mir-1182/Downstream/7010567;
Nearest TSS
ENST00000473358/Upstream/50759; ENST00000493413/Downstream/28790;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/388527, chr1-CpG: 69/Downstream/669231
Nearby gene
GS1-279B7.1(-370722) ; HMCN1(+28790) ;
Upstream sequence
AAATATTGACCCCTAATACTTGTTTCAGTATCAAACCtggagctgatatttaatggagatttactgattgctagacaccgtgctagtgccttgccctagc
Downstream sequence
tgtcatatttaatcatcccaacaaccccatgaggGGGATCAAAAAGCACTATTAGTTGCAGGTTATGACAAAACACAATAACATTTAACTAAAGCACTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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