Basic Information
VIS ID
TVIS10010526
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
543
Orient
+
Integrated sequence
TCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAA| |GGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTAT
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
186278472/186309340 (Hg38)
End
186278472/186309340 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1K
Target gene
MIR548F1 ; RNU6-72P
Nearest miRNA
hsa-mir-101-1/Upstream/5870950; hsa-mir-1182/Downstream/6406988;
Nearest TSS
ENST00000473358/Upstream/13061; ENST00000574641/Downstream/13361;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/992106, chr1-CpG: 69/Downstream/65652
Upstream sequence
TTACCTGACCTTGTTAGCTTGTGAAGTTTTACAGCTTCCCTGTAGGTAAGCAGAGGTGTAATTACAGTAAGCTTTTTCATTCTCTAGAAAATTAAGCCTG
Downstream sequence
GGAATTTAGCATATGTGTGTCTGTGAGCAGCAGAGATGGTATATAGAAAGTCAAAAAAATTTAGTTCGGAGTCTATTCTTAAAAGTACAATGCAAAGCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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