Basic Information
VIS ID
TVIS10010530
Fusion event
HBV-MIR181A1HG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
397
Orient
-
Integrated sequence
TGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTA| |TCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTC
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
198886788/198917659 (Hg38)
End
198886788/198917659 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
MIR181A1HG
Nearest miRNA
hsa-mir-101-1/Upstream/58506; hsa-mir-1182/Downstream/2801849;
Nearest TSS
ENST00000473358/Upstream/90443; ENST00000422480/Downstream/19751;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/758425, chr1-CpG: 36/Downstream/1117687
Upstream sequence
gcagaaattgtgctttttgcaaataaaatgcttgtagcaaccctgcattgagcaagtctgtctgtgccatttttccagtagcatgtgctctttttgtgcc
Downstream sequence
tctttgtcacattttggtaactctctcaataattcagaacttttcattattattttatctgttatggcaatctatgatcagtgattttttatatttactg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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