VISDB Viral Integration Site DataBase

VIS ID

TVIS10010531

Fusion event

HBV-USP48 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

365

Orient

+

Integrated sequence

CTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCC| |TGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATG

Chromosome

chr1

Cytoband

p36.12

Reference genome

Start

End

22082590/21756097 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-148b-3p ; hsa-mir-580-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4539 ; hsa-mir-545-5p ; hsa-mir-8063 ; hsa-mir-374b-3p ; hsa-let-7i-3p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-1468-3p ; hsa-mir-5590-3p ; hsa-mir-545-3p ; hsa-mir-142-5p ; hsa-mir-646 ; hsa-mir-548p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-1305 ; hsa-mir-943 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-1290 ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-1246 ; hsa-mir-892a ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-106a-5p ; hsa-mir-106b-5p

Nearest miRNA

hsa-mir-12136/Upstream/767665; hsa-mir-101-1/Downstream/510142;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/86181, chr1-CpG: 111/Downstream/26539

Upstream sequence

tctactaaaaatacaaaattagccgggcgtggtggtgcacgcctgtaatcccagctactcgggaggctgaggcaggagaattgcttgaacctgagaggcg

Downstream sequence

gaggttgtggtgaaccgagattgtgccattgcactagagcgtgggcaacaagtgtgaaactgtcttaaaaaaataataataataataataaaataaGTTT