Basic Information
VIS ID
TVIS10010537
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1661
Orient
-
Integrated sequence
TTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGA| |GGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTT
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
44109130/43643459 (Hg38)
End
44109130/43643459 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12136/Upstream/194848; hsa-mir-101-1/Downstream/195163;
Nearest TSS
ENST00000473358/Upstream/30319; ENST00000463151/Downstream/6690;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37988, chr1-CpG: 49/Downstream/6486
Nearby gene
PTPRF(-19787) ; KDM4A(+6667) ;
Upstream sequence
tcaataatagaaaggagggaaatactgatgcatgctacaacatgggtgactctcaaaaaaattatgctcagtgaaagaagccagacacaaaagaccacat
Downstream sequence
agtctatggttctatttatatgaaatgtccagaaaaggcaaatctatatagacagaaaatagattaataattgcctggggctgggggtgggaatggagac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate