VISDB Viral Integration Site DataBase

VIS ID

TVIS10010538

Fusion event

HBV-MMACHC integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1756

Orient

-

Integrated sequence

TAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATT| |AGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATG

Chromosome

chr1

Cytoband

p34.1

Reference genome

Start

End

45976539/45510867 (Hg38)

Orient

+

Location type

UTR3

Target gene

miRNAs that regulate target gene

hsa-mir-98-5p ; hsa-mir-342-5p ; hsa-let-7b-5p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3174 ; hsa-mir-3612 ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6832-5p ; hsa-mir-6840-3p ; hsa-mir-6869-5p

Nearest miRNA

hsa-mir-12136/Upstream/965315; hsa-mir-101-1/Downstream/5548970;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/10490, chr1-CpG: 64/Downstream/10624

Upstream sequence

GTAGTCACACTGAGACTTTAACTGGTAACCCAGCCTGTGGCGTCAGTCGCAGTGCTCTGGCCAACACTATAGCAGGGCTTATTCTTCTCCCTCATGTGTA

Downstream sequence

GTGAAACAAAATGTAACACCTTGGGTTCATTCAGTTCCATTCCCTATATCTACCTGTGTCAATATAATTCCCTGATTTGGAGGCAGCTCTCCTCATTTTC