LRRC7 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010543
Fusion event
HBV-LRRC7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
-
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
70162783/69697100 (Hg38)
End
70162783/69697100 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1C ; FRA1L
Target gene
LRRC7
Nearest miRNA
hsa-mir-101-1/Upstream/1513490; hsa-mir-11399/Downstream/1370531;
Nearest TSS
ENST00000473358/Upstream/128650; ENST00000415775/Downstream/63075;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/128288, chr1-CpG: 17/Downstream/222260
Nearby gene
DEPDC1(-1199984) ; LRRC7(+63075) ;
Upstream sequence
CTACCTTCCTTTTTAAGATCAATCAGATCTGGGTCTATCCTTTTGCTCTTAATATTTGTTTCTTTCAAGCATCAAGATTCCATTCTCTATTTCATGGCTA
Downstream sequence
TCTAATTTGTCTCATAAAATCTCTATGTTTCTCATAAGGAAATCTCTCTTTTCCTCCAAAGTAATCAACTAGTTTTTCTATTTTTTTATTTTTTTCCCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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