Basic Information
VIS ID
TVIS10010548
Fusion event
HBV-LINC01435 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
109782501/108022743 (Hg38)
End
109782501/108022743 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LINC01435
Nearest miRNA
hsa-mir-107/Upstream/3754338; hsa-mir-202/Downstream/2875347;
Nearest TSS
ENST00000439456/Upstream/858209; ENST00000421481/Downstream/17956;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/107537, chr10-CpG: 63/Downstream/443426
Nearby gene
SORCS1(-858035) ; RNU6-53P(+1147914) ;
Upstream sequence
ccaaaaatggatcccttccttacaccttgtataaaaattcattcaagatggattaaagacttacatgttagacctaaaaccataaaaagcctagaagaaa
Downstream sequence
acctagacaataccattcaggacataggcatgggcaaggacttcatgtctaaaacaccaaaagcaatggcaacaaaagccaaaattgacaaatgggatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate