Basic Information
VIS ID
TVIS10010571
Fusion event
HBV-CHAT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr10
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
50856775/49648729 (Hg38)
End
50856775/49648729 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
CHAT
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30b-5p
Nearest miRNA
hsa-mir-1265/Upstream/663142; hsa-mir-107/Downstream/1650844;
Nearest TSS
ENST00000439456/Upstream/11200; ENST00000638683/Downstream/3007;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/34109, chr10-CpG: 34/Downstream/30790
Upstream sequence
CCATGCTGGGCCCAAAAAAATGTGGGTGGTCGCTGGGGGCTGTGTCAGTCTGGAAAGCGTCTTAACAAAAGATGAATTTGAAAAAAATGTGTACTATaca
Downstream sequence
cacacacacacacacacacacacacacacGATGAATTTGAAACCCAGCTTTGTATGCGACATCATGTGCTTCACGGGCCATGGATAGGAGGCAGCAGATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate