Basic Information
VIS ID
TVIS10010582
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
109
Orient
-
Integrated sequence
ACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCT| |CTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGG
Host Sequence
Chromosome
chr11
Cytoband
q11
Reference genome
GRCh37/hg19
Start
51586926/54532352 (Hg38)
End
51586926/54532352 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-129-2/Upstream/6435494; hsa-let-7a-2/Downstream/2211521;
Nearest TSS
ENST00000527297/Upstream/4233734; ENST00000319760/Downstream/71646;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/4233751, chr11-CpG: 94/Downstream/1340240
Nearby gene
OR4C46(-70715) ;
Upstream sequence
gtgaagatgaacccgtttccaacgaaatcttcaaagaggtccacatatccacttgcagattccaaagaaagagagtttcaaaactgctccatcaacagga
Downstream sequence
gtgttcaactctgtgagttgaatgcagtcctcacaggaaacattctgagaatgcttctgtctaggtttgatgtgaagatatacccgtttcgaaggaaggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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