Basic Information
VIS ID
TVIS10010584
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1741
Orient
+
Integrated sequence
GCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAG| |TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
7201280/7180049 (Hg38)
End
7201280/7180049 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/3323908; hsa-let-7a-2/Downstream/54717;
Nearest TSS
ENST00000527297/Upstream/91022; ENST00000534653/Downstream/42884;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/89904, chr11-CpG: 140/Downstream/71477
Nearby gene
RBMXL2(-88901) ; SYT9(+71901) ;
Upstream sequence
ttaataaatggtgctgggaaaactggctagccatatgtagaaagctgaaactggatcccttccttacaccttatacaaaaattaattcaagatggatgga
Downstream sequence
agacttaaatgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccatttaggacataggcatgggcaaggacttcatgtctaaaaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate