Basic Information
VIS ID
TVIS10010587
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2557
Orient
+
Integrated sequence
TCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACAT| |TTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATC
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
97948546/98077818 (Hg38)
End
97948546/98077818 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/1736292; hsa-let-7a-2/Downstream/3442002;
Nearest TSS
ENST00000527297/Upstream/135056; ENST00000532109/Downstream/598573;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1687395, chr11-CpG: 34/Downstream/942995
Nearby gene
JRKL-AS1(-1708505) ; CNTN5(+943160) ;
Upstream sequence
TCTTTTTTTTGCATAGTGGAAAATTTCAACTTGTAGCTTTTCTTTTAAAAAACTTTCAGTCATTGGATATGTGTGAGCGTGAGATAACTTCATTTTCTAT
Downstream sequence
TTTAAATATGTTATTTATCCAAACAAAACAACTTCATGAAGTTTAAATAGAATGCACAATTATCACGAtgttaaagtatgcccctggccaacagacaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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