Basic Information
VIS ID
TVIS10010590
Fusion event
HBV-KCCAT198 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1775
Orient
+
Integrated sequence
TCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTAC| |TAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCC
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
105710856/105317078 (Hg38)
End
105710856/105317078 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCCAT198
Nearest miRNA
hsa-let-7i/Upstream/725362; hsa-mir-1178/Downstream/3318732;
Nearest TSS
ENST00000382841/Upstream/80840; ENST00000546866/Downstream/9939;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/80757, chr12-CpG: 83/Downstream/13416
Nearby gene
APPL2(-80848) ; C12orf75(+13558) ;
Upstream sequence
gcagtgagctgaacacactgcagcctgggcaacataggaagaccctgtgagggaaagaaaagaaaggaagaaaggaagaaaggaagaaagaaagggaagg
Downstream sequence
aaggagaaaggaagtagaaagagagagaggaaagaaggaaggaaagaagaaagggaggaaggagagcaagggaaagagaaagaaggagagagaaaggaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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