Basic Information
VIS ID
TVIS10010606
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1952
Orient
+
Integrated sequence
CATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTC| |GTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCT
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
5652852/5543686 (Hg38)
End
5652852/5543686 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3649/Upstream/3883306; hsa-let-7i/Downstream/1420013;
Nearest TSS
ENST00000382841/Upstream/32029; ENST00000538418/Downstream/19651;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/48862, chr12-CpG: 17/Downstream/284024
Nearby gene
NTF3(-48387) ; ANO2(+18965) ;
Upstream sequence
attaagctactcaagtagataccagagaaaggtgaaaaacaacttaaagaaatttaaaaaacaatacaggatattgtttaaaaaattctccagagaaata
Downstream sequence
ggtaacacaaagaaaaaacaatcacaacttctggaaatgaaagacacacttagaaaaatacaaaatgcactggaaagtgtcaacaatagactagaacaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate