VISDB Viral Integration Site DataBase

VIS ID

TVIS10010612

Fusion event

HBV-WNK1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1957

Orient

-

Integrated sequence

CCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTT| |TGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCA

Chromosome

chr12

Cytoband

p13.33

Reference genome

Start

End

893268/784102 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-192-5p ; hsa-mir-215-5p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-550a-5p ; hsa-mir-106b-3p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-331-3p ; hsa-mir-378a-3p ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-149-5p ; hsa-mir-125b-5p ; hsa-mir-183-5p ; hsa-mir-197-3p ; hsa-let-7b-5p ; hsa-let-7a-3p ; hsa-let-7b-3p ; hsa-let-7f-1-3p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-32-3p ; hsa-mir-98-3p ; hsa-mir-381-3p ; hsa-mir-590-3p ; hsa-mir-300 ; hsa-mir-1297 ; hsa-mir-4465 ; hsa-mir-4666a-3p ; hsa-mir-7849-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-155-5p ; hsa-mir-548a-3p ; hsa-mir-606 ; hsa-mir-548e-3p ; hsa-mir-548f-3p ; hsa-mir-302f ; hsa-mir-4639-5p ; hsa-mir-4775 ; hsa-mir-548ar-3p ; hsa-mir-548az-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-199a-5p ; hsa-mir-5007-3p ; hsa-mir-6755-3p ; hsa-mir-302a-5p ; hsa-mir-1279 ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-5582-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-4789-5p ; hsa-let-7f-2-3p ; hsa-mir-101-3p ; hsa-mir-4272 ; hsa-mir-5697 ; hsa-mir-144-3p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-2682-3p ; hsa-mir-6781-3p ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-130b-5p ; hsa-mir-6849-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-4700-3p ; hsa-mir-6772-3p ; hsa-mir-6780a-3p ; hsa-mir-6509-3p ; hsa-mir-4795-3p ; hsa-mir-4477a ; hsa-mir-4448 ; hsa-mir-4268 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p ; hsa-mir-8063 ; hsa-mir-126-5p ; hsa-mir-944 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-506-3p ; hsa-mir-141-5p ; hsa-mir-24-1-5p

Nearest miRNA

hsa-let-7i/Downstream/876213;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/29855, chr12-CpG: 78/Downstream/165213

Upstream sequence

tgagcccaggagtttgagaccaggctaggcaacaaaccaagatgctgtctccaccaaaaaaaaaaaaaagtatccaggcacagtggcatgtgcctgtagt

Downstream sequence

cccagctacctgggaggctgaggtgggaggattgcttgagcccaggagttttgagaccacagtgagccatgattgtgcccctgtgctccaacctgggtat