Basic Information
VIS ID
TVIS10010613
Fusion event
HBV-DDX11L8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3039
Orient
+
Integrated sequence
GATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTT| |TGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCT
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
93142/12596 (Hg38)
End
93142/12596 (Hg38)
Orient
+
Location type
Intronic
Target gene
DDX11L8
Nearest miRNA
hsa-let-7i/Downstream/1647719;
Nearest TSS
ENST00000382841/Downstream/25506;
Nearest CpG islands
None/Target, None/Upstream, chr12-CpG: 104/Downstream/18193
Nearby gene
WASH8P(-1879) ; FAM138D(+54804) ;
Upstream sequence
ACCAGCTGCTCCGTTCTACCATTTCTTCAGCCCTCTTCGCTGTGCCTGCGGCTCTGCCCCTCCCCTCTCTGCACCTACCACACAGAGAGGCCTTGTTGAG
Downstream sequence
CTCAGAGATCCCACCTAGGCCAATCCACTGGGTTCTGCGGCAGCGATGGCCTGCCTGATCTTCCACCTGCTCTCCCAGGGCCAAAGCCAGAGCTGCTGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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