VISDB Viral Integration Site DataBase

VIS ID

TVIS10010614

Fusion event

HBV-TMCC3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1986

Orient

+

Integrated sequence

TGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGA| |GATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCT

Chromosome

chr12

Cytoband

q22

Reference genome

Start

End

94998763/94604987 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-6864-5p ; hsa-mir-6126 ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-4635 ; hsa-mir-4511 ; hsa-mir-3133 ; hsa-mir-548x-3p ; hsa-mir-5582-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac

Nearest miRNA

hsa-let-7i/Upstream/33635; hsa-mir-1178/Downstream/229411;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/144456, chr12-CpG: 90/Downstream/44788

Upstream sequence

ctgagaaggtgataattgacttagaGGCAGCTCAAAAATCTGCTGAGAGCCTAGCAAGGAGCACATTGTATCTGCAGAAGGAAAAACTAGAATATGTATT

Downstream sequence

TAGGAAACTAAAAGTTGGAGTGTCTAAAATTGAGAATGGCTAAATGGGTCATTCTAAATCAAGGCATGATTGAGGGCTGGGGTGAAAAAGAGGTGCATGG