Basic Information
VIS ID
TVIS10010616
Fusion event
HBV-FGF14-IT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2621
Orient
+
Integrated sequence
CCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAA| |GAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGT
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
103029916/102377566 (Hg38)
End
103029916/102377566 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
FGF14-IT1
Nearest miRNA
hsa-mir-1297/Upstream/331562; hsa-mir-1267/Downstream/5153605;
Nearest TSS
ENST00000623511/Upstream/10002; ENST00000606448/Downstream/17064;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/460441, chr13-CpG: 60/Downstream/16764
Upstream sequence
GACTAATATTAGAGTACATACAAGAAAAGCAGGTATCTTAATATTCTAGCACAGATAAAGggccaggcgcagtggctcacgcctgtaatcccagcacttt
Downstream sequence
gggaggttgaggcaggcagatcacctgaggttgggaattcaagaccagcctgaccaacatggagaaaccccatctctactaaaaatacaaaattagctgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate