VISDB Viral Integration Site DataBase

VIS ID

TVIS10010617

Fusion event

HBV-HMGB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

376

Orient

-

Integrated sequence

TTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCT| |GGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTG

Chromosome

chr13

Cytoband

q12.3

Reference genome

Start

End

31037264/30463127 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-22-3p ; hsa-mir-193b-3p ; hsa-mir-877-3p ; hsa-mir-652-3p ; hsa-mir-18a-3p ; hsa-mir-181d-5p ; hsa-mir-148b-3p ; hsa-mir-328-3p ; hsa-let-7g-5p ; hsa-mir-148a-3p ; hsa-mir-100-5p ; hsa-mir-92a-3p ; hsa-mir-26b-5p ; hsa-let-7e-5p ; hsa-let-7b-5p ; hsa-mir-218-5p ; hsa-mir-153-3p ; hsa-mir-3177-5p ; hsa-mir-571 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-6798-5p ; hsa-mir-3174 ; hsa-mir-4433b-3p ; hsa-mir-219a-1-3p ; hsa-mir-5089-5p ; hsa-mir-6807-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-4252 ; hsa-mir-619-5p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-595 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-4699-3p ; hsa-mir-1179 ; hsa-mir-374c-3p ; hsa-mir-8084 ; hsa-mir-4798-5p ; hsa-mir-3152-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-648 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-142-3p ; hsa-mir-4460 ; hsa-mir-4727-3p ; hsa-mir-6809-5p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4742-5p ; hsa-mir-3677-5p ; hsa-mir-1183 ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-6868-3p ; hsa-mir-6881-3p ; hsa-mir-1236-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-670-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-452-3p ; hsa-mir-4778-3p ; hsa-mir-6870-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-141-5p ; hsa-mir-6515-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-891b ; hsa-mir-4772-3p ; hsa-mir-129-5p ; hsa-mir-1200 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-4682 ; hsa-mir-4424 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-106a-3p ; hsa-mir-4275 ; hsa-mir-4284 ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-1304-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6890-3p ; hsa-mir-122-3p ; hsa-mir-6878-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-4707-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-212-5p ; hsa-mir-205-5p ; hsa-mir-21-5p ; hsa-mir-181b-5p ; hsa-mir-193a-3p ; hsa-mir-320a ; hsa-mir-200a-3p ; hsa-mir-34a-5p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-191-3p ; hsa-mir-4436a ; hsa-mir-4668-5p ; hsa-mir-4733-3p ; hsa-mir-5000-3p ; hsa-mir-548a-3p ; hsa-mir-548ae-3p ; hsa-mir-548ah-3p ; hsa-mir-548aj-3p ; hsa-mir-548am-3p ; hsa-mir-548aq-3p ; hsa-mir-548ar-3p ; hsa-mir-548av-3p ; hsa-mir-548az-3p ; hsa-mir-548e-3p ; hsa-mir-548f-3p ; hsa-mir-548j-3p ; hsa-mir-548x-3p

Nearest miRNA

hsa-mir-2276/Upstream/6300623; hsa-mir-1267/Downstream/9200907;

Nearest TSS

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/17127, chr13-CpG: 42/Downstream/1106

Upstream sequence

GGGAACACTCCCACCCAACAGGAATTTTATACTATTTAAATATAACCAATATGAACAAGTATTAGCTAAGAAACTTTGATTGTACATTTACACTCTAAAC

Downstream sequence

TGACAAAGTAGCTTGCTAAATTTCTCTCAGATTCTACTGTAAAACGTGTCTGGGAAGTAAAAACAGGCAAGATACTCACGGAGGCCTCTTGGGTGCATTG