Basic Information
VIS ID
TVIS10010618
Fusion event
HBV-MIR548F5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2525
Orient
-
Integrated sequence
GATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTC| |ATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAG
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
36177658/35603521 (Hg38)
End
36177658/35603521 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR548F5
Nearest miRNA
hsa-mir-2276/Upstream/11441017; hsa-mir-1267/Downstream/4060513;
Nearest TSS
ENST00000623511/Upstream/10515; ENST00000461581/Downstream/67529;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/124539, chr13-CpG: 75/Downstream/527382
Upstream sequence
ATGTTTCTTGCGCCTTTGTGAATCTAATTTAATGACTTTCAGTGAAATTGCATTGTAGTGGTAAGTAGGTTAATAATGACCACATATTTTATACAGGAAA
Downstream sequence
GAATGGGAAATAATATATGAAAAACATTATAGAGTGCCAAGATGGTATAAGATAAATTAAGACTATTTTAGTTGTTTAAATAAAACTAAATATATTTTGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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