Basic Information
VIS ID
TVIS10010620
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
329
Orient
+
Integrated sequence
TCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTC| |CAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTC
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
83109767/82535632 (Hg38)
End
83109767/82535632 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/4837516; hsa-mir-1267/Downstream/5083033;
Nearest TSS
ENST00000623511/Upstream/1285194; ENST00000446314/Downstream/1346761;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1880322, chr13-CpG: 18/Downstream/1343897
Nearby gene
SLITRK1(+1341576) ;
Upstream sequence
taggaagtctaaggaagaaagagaagaagcagatagaaatcagaaataaaagaggagagataacaactgatgttacagaaataaaagagataaactaata
Downstream sequence
tacataattatatgtcaaaaaattggataatctaaaagaaatgaataaattccgagaaacatagaacctacaaagattgtatcatgaagaaacagaaaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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