MEG8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010623
Fusion event
HBV-MEG8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3102
Orient
-
Integrated sequence
TTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCT| |CCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
101356285/100889948 (Hg38)
End
101356285/100889948 (Hg38)
Orient
-
Location type
Intronic
Target gene
MEG8
Nearest miRNA
hsa-mir-1260a/Upstream/5165; hsa-mir-1185-1/Downstream/21191;
Nearest TSS
ENST00000550708/Upstream/5101; ENST00000614605/Downstream/4822;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/6425, chr14-CpG: 48/Downstream/175358
Nearby gene
RTL1(-5101) ; MEG8(+4822) ;
Upstream sequence
CCTGTCGGGCCTCCAAATTCTGGCTTTAGATGGGCACTCTGGGATTCCCATCTGGCTTCACCTGCCTACCAGCTGGCCTGCCATAGCCTGGGCCCTGCCT
Downstream sequence
CTTCTCTGCGCTTTGCAGAAATCATATTCTCAGTCCTTCAGCTGTGGCTCAATACATGTTGTTCTCAAATCTCATGACAGTTTCTTTAAGAAATATCTAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate