Basic Information
VIS ID
TVIS10010625
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
996
Orient
+
Integrated sequence
TGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAAC| |GAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCAC
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
19187947/18411470 (Hg38)
End
19187947/18411470 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1185-1/Downstream/2611844;
Nearest TSS
ENST00000550708/Downstream/184840;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/2353003, chr14-CpG: 66/Downstream/172276
Nearby gene
OR11H12(+189647) ;
Upstream sequence
GAGAGCATGGGACAGAGGATGCCCCAATGTGAGAACAAGTGAAAAAACCCAGGCTTTTCAGAAACGATTTCCACTGGAGCACAGCTTCCCACATCACATG
Downstream sequence
TAAAAGTCCGGGTTCCTCTCGGTCTTTGGATGTCTCATCTATGTCATCCTCTTCTTCATTCGCTTTCACCTACCTGGGTGCTTCATACTCCATGGCTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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