VISDB Viral Integration Site DataBase

VIS ID

TVIS10010630

Fusion event

HBV-GPHN integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1640

Orient

-

Integrated sequence

CGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATAT| |TGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGA

Chromosome

chr14

Cytoband

q23.3

Reference genome

Start

End

67016914/66550196 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-375

Nearest miRNA

hsa-mir-208a/Upstream/1079010; hsa-mir-1185-1/Downstream/891659;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/40679, chr14-CpG: 95/Downstream/690840

Upstream sequence

tttcagctttcaattcatattaagaaatacattttgaaaggctatatagctaccatagatagtaattcctttgatggatctgagcaaagtaagtgaaaaa

Downstream sequence

ccttccggaaggaattcagcattcttgataccattcagaacaatcatgattcatgcgaggaggtcaaaatgtcaacattaacagtaatttggaagaagtt