Basic Information
VIS ID
TVIS10010639
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2096
Orient
+
Integrated sequence
ATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACT| |AATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGG
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
85580675/85114331 (Hg38)
End
85580675/85114331 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/7848041; hsa-mir-1185-1/Downstream/8833895;
Nearest TSS
ENST00000550708/Upstream/1199281; ENST00000554753/Downstream/125143;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/3580241, chr14-CpG: 45/Downstream/415819
Nearby gene
FLRT2(+415813) ;
Upstream sequence
ATGCCCTGACCTGAATATGTGAGATCCTGGAGAGTAGAAAGCACAATCTCTGGCTAGTCTTCCCCAAGTGTTCCCTAAACAGACTCTGAAGGACTAGCTA
Downstream sequence
TTGATGGAAGTGCAAATTGTGCATTTATGCAGCACTTTGGCTCCAGGATCCGAATATCTTGGATTTAATCCTGAGAGGGTACATTTTCACATTTTACCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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