Basic Information
VIS ID
TVIS10010641
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr14
Cytoband
q32.12
Reference genome
GRCh37/hg19
Start
93324214/92857869 (Hg38)
End
93324214/92857869 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/15591579; hsa-mir-1185-1/Downstream/1090357;
Nearest TSS
ENST00000550708/Upstream/24743; ENST00000554653/Downstream/28483;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/63290, chr14-CpG: 75/Downstream/65031
Nearby gene
GOLGA5(-17910) ; CHGA(+65231) ;
Upstream sequence
ctgaaactggatcccttccttacacctcatacaaaaattaattcaagatggattaaagacttaaatgttagaccgaaaaccataaaaaccctagaagaaa
Downstream sequence
acctagacaataccattcaggacataggcatgggcaaggacttcatgtctaaaacaccaaaagcaatggcaacaaaagccaaaattgacaaatgggatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate