Basic Information
VIS ID
TVIS10010643
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1605
Orient
+
Integrated sequence
CCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACG| |TCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCA
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
96956885/96490548 (Hg38)
End
96956885/96490548 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/1352562; hsa-mir-1185-1/Downstream/3618871;
Nearest TSS
ENST00000550708/Upstream/7566; ENST00000556248/Downstream/10885;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/66252, chr14-CpG: 113/Downstream/11269
Nearby gene
AK7(-1121) ; PAPOLA(+11828) ;
Upstream sequence
aaatgctaacaataaccggagccttcggtgagttgtaatctttttgttggtagagggtcttgcctcaattctgatggctgacgactgatcagggtggtgg
Downstream sequence
ctgctgaaggttggggtagctatggcaatttcttaaaataagacagcaatgggctgggcacagtaggctcatgcctgtaatcccagcactttgggaggct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate