VISDB Viral Integration Site DataBase

VIS ID

TVIS10010648

Fusion event

HBV-MEIS2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1758

Orient

-

Integrated sequence

AGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAG| |GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC

Chromosome

chr15

Cytoband

q14

Reference genome

Start

End

37317729/37025528 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-204-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-218-5p

Nearest miRNA

hsa-mir-1233-1/Upstream/52627; hsa-mir-10393/Downstream/4666057;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/136816, chr15-CpG: 27/Downstream/72446

Upstream sequence

ACCTTATACATGGTAGAGATTTCTTTCACCGTGCCCTGAAATGTTTGCTTTTATCAACACAAAGAGTTAACAGATTGTCCTCACTATCTAAAGGTAGGAA

Downstream sequence

AGTCACTTTTTTTTTTAAATGAATTACAGACATTTCTATTGTCTGCTCCAACCACAGAGGTCCAACCATAGAGTCATGAGAATTTAAGCATACCTCTTTT