Basic Information
VIS ID
TVIS10010651
Fusion event
HBV-LOC107983981 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2672
Orient
+
Integrated sequence
ATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAAT| |ATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGG
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53310341/53018144 (Hg38)
End
53310341/53018144 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107983981
Nearest miRNA
hsa-mir-10393/Upstream/740944; hsa-mir-11181/Downstream/2354796;
Nearest TSS
ENST00000557528/Upstream/213202; ENST00000559915/Downstream/98221;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/211865, chr15-CpG: 33/Downstream/741314
Nearby gene
ONECUT1(-228132) ; WDR72(+495597) ;
Upstream sequence
aggtagaagagagcccagattgtgccactgcactccagcctgggtgacagagtgagactccatctcaaaaaccaaaacaaaacaaaaaccaaaacacaaa
Downstream sequence
atgctactgattttttttacattggttttgtatcctgaaacttttactgaagttgtttatcagttctgcaagcctttggcagagtcttcagggttttcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate