Basic Information
VIS ID
TVIS10010652
Fusion event
HBV-LOC107983981 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
438
Orient
-
Integrated sequence
ACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTG| |TTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTG
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53310355/53018158 (Hg38)
End
53310355/53018158 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107983981
Nearest miRNA
hsa-mir-10393/Upstream/740958; hsa-mir-11181/Downstream/2354782;
Nearest TSS
ENST00000557528/Upstream/213216; ENST00000559915/Downstream/98207;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/211879, chr15-CpG: 33/Downstream/741300
Nearby gene
ONECUT1(-228146) ; WDR72(+495583) ;
Upstream sequence
ccagattgtgccactgcactccagcctgggtgacagagtgagactccatctcaaaaaccaaaacaaaacaaaaaccaaaacacaaaatgctactgatttt
Downstream sequence
ttttacattggttttgtatcctgaaacttttactgaagttgtttatcagttctgcaagcctttggcagagtcttcagggttttctaggtatggaattata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate