Basic Information
VIS ID
TVIS10010653
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
56769125/56476927 (Hg38)
End
56769125/56476927 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/1103893; hsa-mir-11181/Downstream/2694256;
Nearest TSS
ENST00000557528/Upstream/11790; ENST00000621974/Downstream/152638;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/11742, chr15-CpG: 88/Downstream/256272
Nearby gene
MNS1(-11790) ; ZNF280D(+153249) ;
Upstream sequence
atcccatttgtcaattttggcttttgttgccattgcttttggtgttttagacatgaagtccttgcccatgcctatgtcctgaatggtattgtctaggttt
Downstream sequence
tcttctagggtttttatggttttaggtctaacatttaagtctttaatccatcttgaattaatttttgtataaggtgtaaggaagggatccagtttcagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate