Basic Information
VIS ID
TVIS10010655
Fusion event
HBV-MIR548H4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1829
Orient
-
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
69368733/69076393 (Hg38)
End
69368733/69076393 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR548H4
Nearest miRNA
hsa-mir-10393/Upstream/274468; hsa-mir-11181/Downstream/1002979;
Nearest TSS
ENST00000557528/Upstream/1809; ENST00000558147/Downstream/4457;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/1937, chr15-CpG: 123/Downstream/83719
Upstream sequence
CACTGAGGACATTCCAAAGAAACTGCTAAGAGAGAATGGCTTGTGCTAGGTGAGTGGAAGTGTTGCATCAGGTTATCACAGCTGGGTATTGAGGCCAGGC
Downstream sequence
CCAGCTGAAATGTTACAGCAGGGGTCACCTCTCAGACTTGGCTCTGTACAGGAAACACATCCAAGGAGGAGCTACATCCAAGGCAAAGGTATAAAGCCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate