VISDB Viral Integration Site DataBase

VIS ID

TVIS10010656

Fusion event

HBV-THSD4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2123

Orient

+

Integrated sequence

CCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGT| |TAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGT

Chromosome

chr15

Cytoband

q23

Reference genome

Start

End

72027799/71735460 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-1909-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-512-3p ; hsa-mir-6768-3p ; hsa-mir-4484 ; hsa-mir-548an ; hsa-mir-4665-5p ; hsa-mir-4472 ; hsa-mir-1275 ; hsa-mir-4447 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-7160-5p ; hsa-mir-6853-5p ; hsa-mir-6087 ; hsa-mir-4649-3p ; hsa-mir-1827 ; hsa-mir-670-5p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-6882-3p ; hsa-mir-1908-5p ; hsa-mir-4749-5p ; hsa-mir-4706 ; hsa-mir-4312 ; hsa-mir-637 ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4308 ; hsa-mir-4292 ; hsa-mir-4438 ; hsa-mir-3925-3p ; hsa-mir-4709-3p ; hsa-mir-665 ; hsa-mir-6863 ; hsa-mir-766-3p ; hsa-mir-873-5p

Nearest miRNA

hsa-mir-10393/Upstream/1655992; hsa-mir-11181/Downstream/851757;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/520103, chr15-CpG: 18/Downstream/76391

Upstream sequence

GGTACACCTAAGGATCCATGGCACTCAGGAAACCCAAGACTCCAGACTCCTACCTCTCCTCCATCTTGAAAACctctctctctctttctcactctctctc

Downstream sequence

tctctctctctttctcactagctctctgtcttgctctctgtctgtccctctctgtctctcttaccatctccctctcttttgctctctctttattgctctc