Basic Information
VIS ID
TVIS10010659
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
85684404/85141173 (Hg38)
End
85684404/85141173 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/2073758; hsa-mir-11181/Downstream/239423;
Nearest TSS
ENST00000557528/Upstream/20982; ENST00000560571/Downstream/239398;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/158539, chr15-CpG: 115/Downstream/92720
Nearby gene
PDE8A(-2028) ; LOC642423(+63503) ;
Upstream sequence
AAAGCAAAGAAGAAATAAAGTGCAACTAATGCAACCAATAAAAGACAAATGGAAAAAGAAAATGCATGAGTTAGAAAAGACAGTGGCAGAAATAAGTATA
Downstream sequence
AACTCATACACAAAATCAATTGTAAAGATCTACATGTAAAAAAAAGTAGCatatggtgaaaccccatctctactaaaaatacaaaaattagctgggcttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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