VISDB Viral Integration Site DataBase

VIS ID

TVIS10010660

Fusion event

HBV-AKAP13 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2379

Orient

+

Integrated sequence

TCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGA| |ACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGG

Chromosome

chr15

Cytoband

q25.3

Reference genome

Start

End

85933932/85390701 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-16-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-8074 ; hsa-mir-6778-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1281 ; hsa-mir-3667-3p ; hsa-mir-6832-3p ; hsa-mir-183-5p

Nearest miRNA

hsa-mir-10393/Upstream/10039; hsa-mir-11181/Downstream/379795;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/9252, chr15-CpG: 20/Downstream/368017

Nearest cancer related gene

AKAP13(OG, No orient, 0)

Upstream sequence

ctcttggcatagggagcagtagtggaaacggagagactagttaagagatttgcagtcgttcaggctagagaagatggtggcttggattagggtggtagca

Downstream sequence

gcgaaagtggtgagaagcggtttgaatccatatacgctgaaaatagaactataggattacttacagattggaaaaaggttctaaaggaaagaaagaaatt