VISDB Viral Integration Site DataBase

VIS ID

TVIS10010674

Fusion event

HBV-NFAT5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

635

Orient

+

Integrated sequence

CTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAA| |ATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCA

Chromosome

chr16

Cytoband

q22.1

Reference genome

Start

End

69657519/69623616 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-31-5p ; hsa-mir-24-3p ; hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-877-5p ; hsa-mir-652-3p ; hsa-mir-17-5p ; hsa-mir-211-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-4690-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-103a-2-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-580-5p ; hsa-mir-651-3p ; hsa-mir-889-3p ; hsa-mir-1252-5p ; hsa-mir-4476 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-6815-3p ; hsa-mir-6826-5p ; hsa-mir-6876-5p ; hsa-mir-3910 ; hsa-mir-548an ; hsa-mir-1468-3p ; hsa-mir-548p ; hsa-mir-921 ; hsa-mir-3174 ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-6507-3p ; hsa-mir-4796-3p ; hsa-mir-374a-5p ; hsa-mir-155-5p ; hsa-mir-7111-5p ; hsa-mir-6883-5p ; hsa-mir-6825-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-1827 ; hsa-mir-4419a ; hsa-mir-5681a ; hsa-mir-205-5p ; hsa-mir-4536-5p ; hsa-mir-6770-5p ; hsa-mir-6073 ; hsa-mir-1253 ; hsa-mir-552-3p ; hsa-mir-6768-5p ; hsa-mir-6505-5p ; hsa-mir-6844 ; hsa-mir-9-5p ; hsa-mir-1-3p ; hsa-mir-206 ; hsa-mir-613 ; hsa-mir-6124 ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-3202 ; hsa-mir-4756-5p ; hsa-mir-3179 ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-4797-3p ; hsa-mir-6512-5p ; hsa-mir-3941 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4261 ; hsa-mir-4496 ; hsa-mir-146a-5p ; hsa-mir-3180-5p ; hsa-mir-345-5p ; hsa-mir-4256 ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-4762-3p ; hsa-mir-520a-5p ; hsa-mir-525-5p ; hsa-mir-6731-3p ; hsa-mir-744-5p ; hsa-mir-1273h-5p ; hsa-mir-17-3p ; hsa-mir-30b-3p ; hsa-mir-3160-3p ; hsa-mir-3192-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-3689d ; hsa-mir-4311 ; hsa-mir-4443 ; hsa-mir-4487 ; hsa-mir-485-5p ; hsa-mir-490-3p ; hsa-mir-558 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6799-5p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6884-5p ; hsa-mir-7106-5p ; hsa-mir-7847-3p ; hsa-mir-7851-3p

Nearest miRNA

hsa-mir-1225/Upstream/57748; hsa-mir-11401/Downstream/309465;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/56783, chr16-CpG: 19/Downstream/102774

Upstream sequence

ttttttttgagatggagtttcactcttattgcccaggctggagtgcaatggtgtgatcttggctcactgcagcctccgcctcccaggtttaagcggttct

Downstream sequence

cctgcctcagcctcccaagtagctgtgattacaggcatgcaccaccatgtccggctaattttgtatttttagtagagacagggtttctccatgttggtca