Basic Information
VIS ID
TVIS10010680
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
680
Orient
-
Integrated sequence
CTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTT| |ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC
Host Sequence
Chromosome
chr17
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
22227618/22728291 (Hg38)
End
22227618/22728291 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/3383717; hsa-mir-10226/Downstream/4565619;
Nearest TSS
ENST00000595228/Upstream/35457; ENST00000583786/Downstream/4271634;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/35609, chr17-CpG: 114/Downstream/4002737
Nearby gene
MTRNR2L1(-203627) ;
Upstream sequence
atcccatatgtcaattttggcttttgttgccattgcttttggtgttttagacatgaagtccttgcccatgcctatgtcctgaatggtattgtctaggttt
Downstream sequence
gcttctagggtttttatggttttaggtctaacatgtaagtctttaatccatcttgaattaatttttgtataagttgtaaggaaaggatccagtttcagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate