Basic Information
VIS ID
TVIS10010685
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
270
Orient
+
Integrated sequence
ATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCT| |CTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTT
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
72122179/74126040 (Hg38)
End
72122179/74126040 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/5026384; hsa-mir-1250/Downstream/622573;
Nearest TSS
ENST00000595228/Upstream/13141; ENST00000528433/Downstream/28172;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/172924, chr17-CpG: 43/Downstream/77753
Nearby gene
LINC00469(-297503) ; RPL38(+77616) ;
Upstream sequence
taaagtgatgctgcgtggagcagaaatgggctgtccccaccacgcctacccaaactgcagattcttgagcaaaataaatgcttattgtttttagacacaa
Downstream sequence
agttttaaattggcttgttgcacagcaatagataactggaacaTCTTTAAATAACTGTCAATCAACCCCTCCCAGACTCCGTTTCCTTATCTGAATTGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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