Basic Information
VIS ID
TVIS10010707
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
491
Orient
+
Integrated sequence
GTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGG| |ATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGA
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
35848300/35357398 (Hg38)
End
35848300/35357398 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/11771; hsa-let-7e/Downstream/4052225;
Nearest TSS
ENST00000633603/Upstream/5846; ENST00000594310/Downstream/1062;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5114, chr19-CpG: 43/Downstream/175882
Nearby gene
FFAR1(-4933) ; FFAR3(+1188) ;
Upstream sequence
acatggtcttttacgtctggcttgtttcactcaacataaggctgtagtgtgtatgggtagctcattccttttctttgccaaatagaattccagtatatgg
Downstream sequence
atgtgccacttttttattcactcaccagctgatgggctgccaggtaacatttccactgttggtgactatgaccaacactgctgtgaacatttaggactga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate